Yes, you can use the Ledger Nano X with Lofty by following the steps below:
Visit the Lofty Marketplace
Click the property listing you want to invest in
Click "invest"
Log In or Sign Up if you aren't yet logged in
Chose your payment method
Accept the exchange rate you see in the payments dialog box
Click the "Pera Wallet" button to initiate payment
Accept the transaction in Pera Wallet - a notification will not be sent, you have to have the wallet open, this is a limitation of Pera Wallet
You ALSO must sign the transaction in Ledger, it should preferably be open while you’re accepting the transaction in Pera Wallet
After you complete these steps, the Lofty will detect and complete the transaction.
If the opt-in step fails or is skipped, you can manually complete opt-in as follows:
Connect your Ledger device via Bluetooth to your phone
Choose the Algorand app on your Ledger
Open Pera Wallet and choose your Lofty wallet address
Click "+ add" (top right highlighted in yellow)
Type the asset ID in the search box
Click on the asset and then click "approve"
Pera Wallet will try to connect to your Ledger Nano X
Follow prompts if successfully connected
After you complete these steps, your Ledger wallet will have successfully opted into the Lofty token asset ID. Outstanding Lofty tokens are automatically issued within 1 hour of completing this step.